MUC5AC and cystic fibrosis: The dysregulation of mucin production in CF airways contributes to the high viscosity and spatial heterogeneity of CF sputum [44] and can alter the dispersal and virulence factor production of P. aeruginosa [13, 45] by altering the expression of P. aeruginosa virulence factors, triggering the down regulation of quorum sensing genes, siderophore production and toxin secretion [45].