Moreover, when we analyzed the patients who were started on dialysis at the time of AAV-GN diagnosis (n = 71), we found that patients who had GPA, were PR3-ANCA positive, or had a SCr <5.7 mg/dl at the time of diagnosis, with focal involvement or minimal or mild chronicity changes were more likely to discontinue dialysis, regardless of the treatment with PLEX, further questioning the utility of PLEX in patients with eGFR <15 ml/min per 1.73 m2. This evidence concerns the gene PRTN3 and ganglioneuroma.