HAMP and anemia (phenotype): For example, when inflammation was mimicked by administration of a hepcidin agonist in an animal study with pregnant mice,51 high doses of hepcidin agonist caused severe hypoferremia and anemia in both the mothers and embryo; whereas low doses of hepcidin agonist did not cause maternal anemia, but still adversely affected the embryo, causing anemia and tissue iron deficiency.