SEC61A1 and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: Several genes have been associated with ADTKD, notably UMOD, encoding uromodulin; MUC1, encoding transmembrane epithelial mucin 1; REN; HNF1B; and SEC61A1. 3According to the latest studies, UMOD represents the most frequent subtype of ADTKD with estimated prevalence of 37.1% followed by MUC1 in 35% of families that are UMOD-negative with an estimated overall prevalence of 21%.4