Pathophysiology of IgAN in liver disease is thought to be due to abnormalities of liver clearance of IgA.15, 16, 17 However, IgA 1, whose misdirected secretion by mucosal immune system is the cornerstone of IgAN pathogenesis, including in patients with cirrhosis,6 is hardly cleared by the liver.17 This evidence concerns the gene CD79A and liver disorder.