We detected anti-C3 and anti-C4 autoantibodies in 23 (27.1%) and 24 (28.2%), respectively, of the patients with LN in a cross-sectional analysis (of which both anti-C3 and anti-C4 was elevated in 11 [12.9%] of the patients) (Table 1, Figure 1a and c). This evidence concerns the gene C4A and lobular neoplasia.