Increased Th1 and Th17 differentiation of CD4 T cellsIncreased conversion of Tregs to Th17Enhanced effector functions of CD8 T cellsEnhanced proliferation of differentiated effector CD8 T cellsPro-inflammatory and pro-oncolytic effects in other immune cellsIncreased intrinsic tumor susceptibility to CD8 cells. This evidence concerns the gene CD8A and neoplasm.