This is because recurrent or de-novo acute proliferative glomerulonephritis causing MVI can be differentiated by a constellation of clinical features and other investigations such as urine microscopy for hematuria, proteinuria, correlation with serum C3 and C4 levels, etc. Similarly, acute pyelonephritis in the post-transplant period can be distinguished by characteristic clinical features such as burning micturition, fever, etc., in addition to urine microscopy for pus cells, neutrophilic leucocytosis, and urine culture. This evidence concerns the gene C3 and acute proliferative glomerulonephritis.