SH3TC2 and Charcot-Marie-Tooth disease: In a more recent large-scale study of patients suspected to have genetic neuropathy, 3.3% of 1,515 patients were identified with mutations in the SH3TC2 gene [16]. The increase in the identification of patients with CMT4C is, in part, due to the improvements in sequencing technology. Nevertheless, CMT4C remains an uncommon condition and an infrequent cause of CMT.