KPS: Karnofsky performance status; ECM: extracranial metastases; BM: brain metastases; EGFR: epidermal growth factor receptor; ALK: anaplastic lymphoma kinase; adeno: adenocarcinoma; non-adeno: non-adenocarcinoma; coef: coefficient; HR: hazard ratio; %: percent; CI: confidence interval; n: number; reference: reference value; NA: not available. The gene discussed is ALK; the disease is adenocarcinoma.