Cytokines such as IL-2, IL-6, TNF-α, IFN-γ, and IL-10 could serve as predictors for early prediction of the severity of COVID-19; hence, this study aimed to evaluate the association of cytokine levels IL-2, IL-6, TNF-α, IFN-γ, and IL-10 with the severity of COVID-19 in Bangladesh. The gene discussed is IL10; the disease is COVID-19.