Mahendra et al. evaluated 60 patients with chronic periodontitis, and those in YG had a statistically significant reduction in the expression of NF-kB and an increase in PPARy expression levels (anti-inflammation causes down-regulation of NF-kB) compared to the CG (received standard of care) (p <0.001) [42]. Here, NFKB1 is linked to chronic periodontitis.