RUNX1 and acute kidney injury: Cantaluppi and colleagues found that endothelial progenitor cell (EPC)-derived EVs could prevent AKI from I/R injury in a rat model, through miR-126 and miR-296-mediated reprograming the hypoxic renal parenchymal cells into a regenerative state.170 Zhang and colleagues also found that EPC-derived EVs could alleviate renal tissue inflammation and apoptosis in rat sepsis-induced AKI via upregulating miR-21-5p expression, resulting in runt-related transcription factor 1 (RUNX1) silencing.