SYK and malaria: The function of the band 3 protein on the erythrocyte membrane is regulated by protein tyrosine phosphatases (PTP), spleen tyrosine kinase (syk) and Src family tyrosine kinase (Lyn), Y-phosphorylation/dephosphorylation is likely involved in the regulation of several erythrocyte functions (Minetti et al., 1998, p. 3; Brunati et al., 2000) Tyrosine phosphorylation of band 3 is induced by many stimuli, such as aging, malaria, and oxidative stress (Ferru et al., 2011, p. 3; Spinelli et al., 2023).