PLD2 and colorectal carcinoma: To get insights into the mechanism of function of PLD2 in CRC cells, high-throughput RNA sequencing (RNA-seq) was performed on PLD2 knockdown CRC cell line SW480 and PLD2 overexpression CRC cell line SW1116 to explore the gene expression profile associated with PLD2, rather than on the samples of CRC patients due to their high heterogeneities.