ACOX2 and posterior cortical atrophy: To identify the biological function of ACOX2 in PCa cell lines, we successfully constructed ACOX2- overexpressing PCa cell lines, PC-3 and 22Rv1; their status was confirmed through a western bolt assay (Figure 8A and Figure s2A, for PC-3: P < 0.0001, for 22Rv1: P < 0.05).