The current work has shown that miR-760 is downregulated in glioma cell lines compared to normal human astrocytes, and miR-760 exerts a tumour suppressive effect in glioma by decreasing cell proliferation and invasion by directly targeting MMP2, suggesting that miR-760 might be a new predictive biomarker and a potential therapeutic target for glioma. The gene discussed is MMP2; the disease is glioma.