Conversely, higher levels of TIE1 were observed in cholangiocarcinoma (CHOL), head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC) and stomach adenocarcinoma (STAD) compared to normal tissues (Figure 1A). Here, TIE1 is linked to head and neck squamous cell carcinoma.