JAK2 and malignant colon neoplasm: Li et al. [85] reported that an amide anthraquinone derivative named 1-nitro-2-acyl anthraquinone glycine (C10) had a high binding affinity to JAK2, leading to downregulation of the JAK2/STAT3 signaling pathway, resulting in the induced cell cycle arrest and inhibiting cell proliferation in HCT116 and HT29 colon cancer cells.