The inverse correlation between GRHL2 and NT5E/CD73 expression was further established in a series of breast cancer cell lines representing Her2 negative luminal (CAMA-1 and T47D), Her2+ luminal (MDA-MB-361 and BT474), TNBC basal A (HCC1806 and HCC1143), and TNBC basal B cell lines (MDA-MB-231 and BT549). The gene discussed is NT5E; the disease is breast carcinoma.