However, other studies performed in African populations exhibited no association between AGT gene polymorphisms and risk of developing hypertension.20,33–35 Furthermore, considering the reduced efficacy of angiotensin receptor blockers (ARBs) in individuals of African ancestry,36,37 a better understanding of genetic differences is imperative to evaluate disease risk and differential drug response of patients of African ancestry to antihypertensive medications. Here, AGT is linked to hypertensive disorder.