MAPT and Alzheimer disease: Similarly, between AD and FP, 18 biological pathways were identified, which include ‘protein-macromolecule adaptor activity’ (padjusted = 1.25 × 10−4), ‘protein homodimerization activity’ (padjusted = 2.11 × 10−4), and ‘tau protein binding’ (padjusted = 4.51 × 10−4) (Supplementary Table S18).