CFI and Alzheimer disease: Of these 8 loci, 5 loci (3q25.1, 4p16.3, 6p21.2, 14q22.1, 18q21.2) were novel for both AD and FI, and 3 loci (11p11.2, 17q21.31, 17q21.33) were novel for FI (Table 1; Figure 2) and had pleiotropy association with AD.