These shared loci present a significant shared genetic association between AD and frailty with a varying posterior probability, with several loci (4p16.3, 7p22.3, 11p11.2, and 17q21.31) and genes (RGS12, MAD1L1, and C1QTNF4) being shared in the SNP meta-analyses and gene analyses. Here, MAD1L1 is linked to Alzheimer disease.