The glycolysis inhibitory effect and apoptosis promoting effect of IDO1 inhibitors (RY103, INCB024360, and 1‐methyl‐l‐tryptophan [1‐MT]) were elucidated in vivo by using orthotopic and tumor‐bearing PC mice, and the therapeutic efficacy of IDO1 and GLUT1 inhibitors combination against PC was evaluated. Here, SLC2A1 is linked to neoplasm.