To this end, the positive correlation between the expression of IDO1 and genes encoding rate‐limiting glycolytic enzymes in PC patients was revealed with bioinformatic tools, the regulatory effect of IDO1 on glycolysis was confirmed in mouse and human PC cells, and the inhibitory effect of IDO1 inhibitors on glycolysis was demonstrated in vivo. Here, IDO1 is linked to pachyonychia congenita.