METTL3 and neoplasm: However, METTL3's impact on tumor progression may occur independently of m6A. For example, irrespective of its catalytic activity, upregulation of METTL3 drives the growth and invasion of LUAD cells by binding to eIF3 and enhancing the translation of target transcripts such as epidermal growth factor receptor (EGFR) and transcriptional co‐activator with PDZ‐binding motif (TAZ).42