FAP and neoplasm: We conducted further assessments on the distribution and accumulation of [177Lu]Lu-DOTA-FD3 in HT1080-FAP tumor models at 45 h and 90 h p.i. Similarly, [177Lu]Lu-DOTA-FD3 was mainly retained in the blood pool at 45 h p.i. (16.34 ± 2.50%ID/g, n = 4) and gradually decreased at 90 h p.i. (11.46 ± 1.54%ID/g, n = 3, Fig. S10).