SIRT1 and rheumatoid arthritis: The SIRT1 SNP rs7895833 A>G is closely associated with an increased risk of developing chronic diseases., such as cardiovascular disease,22,25 chronic obstructive pulmonary disease,21 Parkinson’s disease,60 type 2 diabetes mellitus,61 rheumatoid arthritis.29 These chronic diseases can contribute to the development of physical frailty in elderly adults by reducing muscle mass, strength, and function11,62 and also anemia.63