Altered SIRT1 levels caused by the SNP could dysregulate these processes and lead to much worse health outcomes, including chronic obstructive pulmonary disease,21 cardiovascular diseases,22 oxidative stress,23 essential hypertension and type 2 diabetes mellitus,24 coronary artery disease,25 rheumatoid arthritis,26 dyslipidaemia,27 metabolic syndrome,28 rheumatoid arthritis,29 and neurodegenerative disease.30 There was limited research on the specific interaction between SIRT1 SNP rs7895833, hemoglobin, age, and physical frailty. This evidence concerns the gene SIRT1 and hypertensive disorder.