The SIRT1 SNP rs7895833 A>G is closely associated with an increased risk of developing chronic diseases., such as cardiovascular disease,22,25 chronic obstructive pulmonary disease,21 Parkinson’s disease,60 type 2 diabetes mellitus,61 rheumatoid arthritis.29 These chronic diseases can contribute to the development of physical frailty in elderly adults by reducing muscle mass, strength, and function11,62 and also anemia.63 The gene discussed is SIRT1; the disease is cardiovascular disorder.