There is also noticeable increased secretion of pro-inflammatory cytokines such as IL-1, IL-6, IFN-γ, TNF-α (IL-1—interleukin 1, IL-6—interleukin 6, INF-y—interferon gamma, TNF-α - tumor necrosis-α) and substances secreted by the tumor such as PIF, PMF, LMF (PIF-protein inducing factor, PMF—protein mobilizing factor, LMF-lipid mobilizing factor) which cause changes in metabolism such as increased lipolysis, proteolysis, glycolysis (2). Here, TNF is linked to neoplasm.