A study found that 1-Methyl-D-tryptophan Reduces Tumor CD133+ cells, Wnt/β-catenin and NF-κβp65 in Murine Pancreatic Adenocarcinoma.1-Methyl-D-tryptophan significantly modulates the regulatory cytokines in the tumor microenvironment, which significantly inhibited tumor growth and tumor immune escaping potency (45). This evidence concerns the gene PROM1 and neoplasm.