CD44 and neoplasm: It is not difficult to understand, as high co-expression of CD44 & CD133 generally indicates high tumor stemness, tumor cells with high tumor stemness may not necessarily exhibit significant tumor proliferation and infiltration behavior in the initial stage of the disease but may lead to the final progression of the disease by bolstering drug resistance, sustaining self-renewal, and facilitating multi-lineage differentiation (2, 3, 23).