apoptosis, autophagy, biomarker, breast cancer, cancer, carcinogenesis,cholangiocarcinoma, diagnosis, dna methylation, drug resistance, emt, gemcitabine, gene expression, gene mutation, genetics, genomics, inflammation, invasion, metastasis, microrna, mirna, mouse model, oncogene, p53, pancreas, pancreatic cancer, pancreatic ductal adenocarcino, pdac, personalized medicine, proliferation, targeted therapy, tumor microenvironment. This evidence concerns the gene TP53 and neoplasm.