apoptosis, autophagy, biomarker, breast cancer, cancer, carcinogenesis,cholangiocarcinoma, diagnosis, dna methylation, drug resistance, emt, gemcitabine, gene expression, gene mutation, genetics, genomics, inflammation, invasion, metastasis, microrna, mirna, mouse model, oncogene, p53, pancreas, pancreatic cancer, pancreatic ductal adenocarcino, pdac, personalized medicine, proliferation, targeted therapy, tumor microenvironment. Here, TP53 is linked to familial pancreatic carcinoma.