apoptosis, autophagy, biomarker, breast cancer, cancer, carcinogenesis,cholangiocarcinoma, diagnosis, dna methylation, drug resistance, emt, gemcitabine, gene expression, gene mutation, genetics, genomics, inflammation, invasion, metastasis, microrna, mirna, mouse model, oncogene, p53, pancreas, pancreatic cancer, pancreatic ductal adenocarcino, pdac, personalized medicine, proliferation, targeted therapy, tumor microenvironment. The gene discussed is TP53; the disease is cancer.