Other markers previously associated with type 2 inflammation in asthma, including CLCA1, SERPINB2, and SPDEF, were significantly (p < 0.0001) increased in the IL-13 treated HBEC compared to normal HBEC (Mertens et al., 2017; Pavlidis et al., 2019; Jackson et al., 2020). This evidence concerns the gene SPDEF and asthma.