We have previously found that CRABP1 is highly expressed in spinal cord, specifically in spinal MNs, not in glia cells [7] and reported that CKO mice, that lost CRABP1, spontaneously develop age-dependent, amyotrophic lateral sclerosis (ALS)-like motor degenerative disease. Here, CRABP1 is linked to amyotrophic lateral sclerosis.