TMPRSS11D and leukemia: GRh2 can cause cell cycle arrest in the G1 phase via Retinoblastoma protein phosphorylation reduction and transcription factor translocation.31, 32, 33 GRh2 is a potential Histone deacetylase inhibitor for leukemia treatment as it effectively induces cell cycle arrest and apoptosis, increased Histone acetyltransferase (HAT) activity and histone acetylation, and can inhibit the growth of human leukemia cells.34