PML and acute promyelocytic leukemia: GRh2 also upregulated Tumor necrosis factor alpha (TNF-α) expression and inhibited Akt phosphorylation, leading to Promyelocytic leukemia/Retinoic acid receptor alpha (PML/PML-RARA) degradation, PML nuclear bodies formation, and activation of the downstream p53 pathway in NB4 cells.