PRKN and Parkinson disease: The autophagy pathway has been dysregulated in both diseases, leading to the accumulation of misfolded proteins, such as α-synuclein and PINK1-PARKIN in the neurons of patients with PD and lipofuscin in retinal pigment epithelium (RPE) cells of patients with AMD (Delori et al., 2001; Lynch-Day et al., 2012).