Pathway analysis on significantly upregulated genes (103 genes identified at an FDR < 0.1 with a greater than 4-fold increase) revealed that genes involved in ECM-receptor interactions were enhanced in the metastatic tumor (SU-DIPG-XIII-FL), suggesting that cell-ECM interactions play a role in enabling DIPG infiltration to the frontal lobe from the pons (Fig. 1a). Here, MMRN1 is linked to metastatic neoplasm.