ITGAV and metastatic neoplasm: The metastatic tumor (SU-DIPG-XIII-FL) showed upregulation of laminin-associated integrins (ITGα3, ITGα6, and ITGα7), fibronectin-associated integrins (ITGαV), and ITGβ1 (ubiquitously involved in multiple interactions) (Fig. 2b, Additional file 1: Figure S2c).