Further analysis using a second LMM considering diet treatment on DR subdivisions revealed an increased htr1a mRNA expression in the cDRD [F(1, 17.4) = 24.5; p < 0.0001; Fig. 4d] in line with the effects of diet treatment on tph2 mRNA expression in this subregion of the DR that has been associated with increased anxiety-like states [13, 50]. The gene discussed is TPH2; the disease is Anxiety.