In addition, corticotropin-releasing hormone (Crh) receptor priming in the bed nucleus of the stria terminalis (BNST) induces increases in tph2 mRNA expression in the cDRD in association with a chronic anxiety-like state, and tph2 mRNA expression in the cDRD is highly correlated with anxiety-like defensive behavioral responses [14]. Here, TPH2 is linked to Anxiety.