TP53 and cerebellar ataxia: Roshan et al. revealed that in Spinocerebellar ataxias 17, downregulation of miR-29a and miR-29b lead to elevation of their target genes; β-secretase 1 (BACE1), p53 upregulated modulator of apoptosis (PUMA), and BAK which result in cytochrome releasing and neuronal apoptosis [30].