Similarly, the alterations in the gene expression of c-Myc, BCL-2, TP53, MDM-2, Rb, BRCA-1, BRCA-2, CDKN-1B, CDKN-1A, and CDKN-1B have shown to be associated with PCa progression14,15, and EBV has been shown to modulate several of these genes in other cancer types4,16, however, the EBV-associated dysregulation of gene expression in PCa has not been explored. Here, RB1 is linked to posterior cortical atrophy.