The SLC3A2-NRG1 fusion protein is composed of a SLC3A2 (SLC3A2 heavy chain) transmembrane domain and the EGF-like domain of the neuregulin 1(NRG1) protein (NRG1 III-β3 form) which its overexpression has been seen in cancer progression. The gene discussed is NRG1; the disease is cancer.