NLRP3 and infection: In the current study, we also paid our attention on the effect of NLRP3 inflammator-mediated pyroptosis on viral replication, and discovered that the activated NLRP3 facilitated the CV-A16 and CV-A10 replication in infected SH-SY5Y cells, and vice versa, probably pointing out that NLRP3 promote a productive infection of CV-A16 and CV-A10.