Next, the mRNA and protein levels of NLRP3, ASC, Caspase1, Gasdermin D, IL-1β and IL-18 were significantly ascended in SH-SY5Y cells stimulated with Nigericin sodium salt prior to CV-A16 or CV-A10 infection, but they were obviously descended in SH-SY5Y cells stimulated with MCC950 sodium prior to CV-A16 or CV-A10 infection (Fig. 6A and B). Here, IL18 is linked to infection.