PFKFB3 and Sepsis: To assess the therapeutic potential of miR-106a-5p in vivo and its reliance on Pfkfb3 inhibition, we established an LPS-induced sepsis model in both Pfkfb3+/+/LysMcre/+ mice (serving as WT controls) and Pfkfb3flox/flox/LysMcre/+ mice.