CA4 and cancer: In line with the cancer cells’ increased uptake of resources, SLC2A1 and SLC2A5 (glucose transporters GLUT1 and GLUT 5) show an eight-fold increased expression, while other members of the SLC2A family (SLC2A12, SLC2A14, SLC2A3) show > 50% decreased expression Finally, while four members of the carbonic anhydrase family (CA1, CA2, CA3, CA4) show > 75% decreased expression, the expression of CA9, which promotes acid tolerance and immunosuppression [32, 33], is increased 32-fold.