Similarly, consistent with the chaotic vascular structure of tumors, there are marked decreases in expression of genes associated with vascular maturation, including multiple members of the angiopoietin and angiopoietin-like families (ANGPT1, ANGPT4, ANGPTL1, ANGPTL5, ANGPTL7) suggesting this family of genes is essential for normal lung tissue function but does not confer a fitness advantage in cancer cells. Here, ANGPTL7 is linked to cancer.