FOXC2 and neoplasm: For example, PGE2 binding with EP1 activates protein kinase C (PKC)/nuclear factor-κB (NF-κB)/human forkhead box protein C2 (FOXC2) and EGFR/PI3K signaling pathways, which increases intercellular adhesion molecule-1 (ICAM-1), thereby causing tumor growth and migration [10–12].