The 15-deoxy-Δ 12,14 prostaglandin J 2 (15-d-PGJ-2) is a PGD2 metabolite and a natural ligand for peroxisome proliferator-activated receptor-γ (PPARγ) which is activated by dependent or non-dependent signaling and exert anti-tumor, anti-inflammatory, and anti-angiogenic actions [36, 37]. The gene discussed is PPARG; the disease is neoplasm.