Compared to stem cells, EVs can be cryopreserved, have lower immunogenicity, and do not cause tumorigenesis.[13, 14] EVs also have the ability to regulate target cell functions, showing great potential as biological macromolecule medicines.[13, 14] Several studies have reported that MSC‐, probiotic‐, and tumor‐derived EVs induce macrophage M2 polarization.[29, 30, 31, 32, 33] The present study aimed to enrich the M2‐polarizing stimulus, IL‐10, in EVs. Here, IL10 is linked to neoplasm.