Plants can employ nitrosative stress (NO burst) to suppress fungal infection.[29] Coordinately, fungi also developed NO‐detoxification system to adapt to nitrosative stress, such as M. oryzae S‐(hydroxymethyl)‐glutathione dehydrogenase Sfa1 and flavohemoglobin MoFhb1 mediated NO detoxification[15, 30] and F. graminearum transcription factor FgAreB.[3a] However, the synthetic pathway of NO in M. oryzae remains elusive, this notion awaits proof by more genetic studies. Here, CD151 is linked to fungal infectious disease.