The cyclic GMP–AMP synthase (cGAS) – stimulator of interferon genes (STING) signaling pathway, as an important cytoplasmic DNA‐sensing pathway, takes part in regulating cancer immune response by triggering the production of type I interferons (IFN).[8] Notably, manganese ion (Mn2+) has been shown to activate STING pathway.[9] When activated by Mn2+, STING can facilitate the production of type I interferons and other pro‐inflammatory cytokines, boosting the immune system to detect and fight against cancer. The gene discussed is IFNA1; the disease is cancer.