GDF15 and neoplasm: Therefore, we examined GDF15 expression in normal mouse AML12 hepatocytes and hepatocellular carcinoma Hepa1‐6 and H22 cells and found that GDF15 expression in Hepa1‐6 and H22 cells was much higher than that in AML12 cells, indicating that the syngeneic mouse tumor model we constructed met the conditions for our gene‐editing therapy experiments (Figure S5A,B, Supporting Information).