Common mouse models of atherosclerosis include 1) Apolipoprotein E deficient (ApoE−/−) mice, 2) LDL‐receptor deficient mice, 3) Apolipoprotein E3‐Leiden mice, 4) PCKS9‐AAV mice, and 5) Apolipoprotein deficient mice (ApoE−/−) crossbred with mutant fibrillin‐1 allele (Fbn1C1039G+/−),[145, 147] each representing a different stage or aspect of atherosclerosis (Figure5). The gene discussed is LDLR; the disease is atherosclerosis.