Earlier studies have shown that IR‐LND, equipped with the ability to accumulate in mitochondria, could effectively trigger the AMPK protein pathway.[13a] Activating the AMPK pathway has been confirmed to lead to the downregulation of TGF‐β, consequently mediating fibrotic alterations in tumor tissues.[11] Consequently, we postulated that IR‐LND and its liposome nanosystem can proficiently diminish the expression of TGF‐β in tumor cells. The gene discussed is TGFB1; the disease is neoplasm.