Considering the multifaceted effects of IR‐LND@Lip, including enhanced cytotoxicity of T cells, downregulation of PD‐L1/TGF‐β dual immune proteins, and reversal of the fibrotic tumor microenvironment in vitro, we hypothesized that it can proficiently alleviate T‐cell exhaustion, consequently enhancing the efficacy of radio‐immunotherapy in vivo. This evidence concerns the gene CD274 and neoplasm.