Moreover, the T cell infiltrations of CD3+, CD4+, and CD8+ T cells, as well as their anti‐tumor capacity, were amplified via immune‐suppression microenvironment reversion through high‐effective collagen, PD‐L1, and TGF‐β co‐inhibition by IR‐LND@Lip in vivo. The gene discussed is CD8A; the disease is neoplasm.