Previously we found that PRMT6, which primarily is expressed in nonparenchymal cells such as liver macrophages, is a key regulator of liver fibrosis development in both high-fat diet and alcohol-fed mice, and loss of PRMT6 promotes fibrosis and steatosis in liver.23 We observed that females have higher levels of PRMT6 protein (Figure 3A) and mRNA (Figure 3B). Here, PRMT6 is linked to steatosis.