PRMT6 and liver disorder: Previously, we identified PRMT6 as a key regulator of liver fibrosis development in mice fed high-fat diet, alcohol, or treated with thioacetamide as well as mice on a chow diet at 1 year of age.18 One of the main protective functions of PRMT6 is macrophage integrin methylation, which reduces their profibrotic function in liver disease induced by multiple factors: high-fat diet, alcohol, thioacetamide treatment, or aging.23 In this study, we found that female sex hormone signaling and specifically, estrogen, suppresses integrin gene expression.