PRMT6 and Hepatic fibrosis: Previously we found that PRMT6, which primarily is expressed in nonparenchymal cells such as liver macrophages, is a key regulator of liver fibrosis development in both high-fat diet and alcohol-fed mice, and loss of PRMT6 promotes fibrosis and steatosis in liver.23 We observed that females have higher levels of PRMT6 protein (Figure 3A) and mRNA (Figure 3B).